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Title: | Voltammetric methods for analytical determination of fleroxacin in quinodis tablets | Authors: | Kapetanović, V Milovanović, L J Aleksić, M Ignjatović, Ljubiša |
Keywords: | Adsorptive stripping voltammetry;Determination;Dpp Polarography;Fleroxacin;Tablets | Issue Date: | Jul-2000 | Journal: | Journal of pharmaceutical and biomedical analysis | Abstract: | The direct current (dc) and differential pulse (dp) polarographic reduction of fleroxacin was done in a wide pH range from 2.48 to 13.00. The appropriate buffer choice was made for its dp polarographic determination in a range from 1.845 to 16.926 microg /ml, at pH 8.50. The adsorptive properties of fleroxacin were investigated in order to achieve an increase in sensitivity and a possibility of fleroxacin determination by applying the adsorptive stripping voltammetric method. The adsorptive processes at the hanging mercury drop electrode were investigated in Britton-Robinson and borate buffers. Adsorptive preconcentration followed by differential-pulse cathodic stripping showed one wave at approximately - 1.1 V being the most sensitive for analytical determination of fleroxacin. Two linear ranges were obtained, the first one from 18.465 to 258.51 ng/ml, and the second one from 3.693 to 18.465 ng/ml. |
URI: | https://dspace.ffh.bg.ac.rs/handle/123456789/1322 | ISSN: | 0731-7085 | DOI: | 10.1016/s0731-7085(00)00289-2 |
Appears in Collections: | Journal Article |
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