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Please use this identifier to cite or link to this item: https://dspace.ffh.bg.ac.rs/handle/123456789/859
Title: In vivo evaluation of different alterations of redox status by studying pharmacokinetics of nitroxides using magnetic resonance techniques
Authors: Bačić, Goran
Pavićević, Aleksandra 
Peyrot, Fabienne
Keywords: Electron paramagnetic resonance (EPR);Magnetic resonance imaging (MRI);Nitroxides;Pharmacokinetics;Reactive oxygen species (ROS);Redox state
Issue Date: Aug-2016
Journal: Redox biology
Abstract: 
Free radicals, particularly reactive oxygen species (ROS), are involved in various pathologies, injuries related to radiation, ischemia-reperfusion or ageing. Unfortunately, it is virtually impossible to directly detect free radicals in vivo, but the redox status of the whole organism or particular organ can be studied in vivo by using magnetic resonance techniques (EPR and MRI) and paramagnetic stable free radicals - nitroxides. Here we review results obtained in vivo following the pharmacokinetics of nitroxides on experimental animals (and a few in humans) under various conditions. The focus was on conditions where the redox status has been altered by induced diseases or harmful agents, clearly demonstrating that various EPR/MRI/nitroxide combinations can reliably detect metabolically induced changes in the redox status of organs. These findings can improve our understanding of oxidative stress and provide a basis for studying the effectiveness of interventions aimed to modulate oxidative stress. Also, we anticipate that the in vivo EPR/MRI approach in studying the redox status can play a vital role in the clinical management of various pathologies in the years to come providing the development of adequate equipment and probes.
URI: https://dspace.ffh.bg.ac.rs/handle/123456789/859
ISSN: 2213-2317
DOI: 10.1016/j.redox.2015.10.007
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University of Belgrade
Faculty of Physical Chemistry
Studentski trg 12-16
11158 Belgrade 118
PAC 105305
SERBIA
University of Belgrade Faculty of Physical Chemistry