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Please use this identifier to cite or link to this item: https://dspace.ffh.bg.ac.rs/handle/123456789/748
Title: Potentiation of the ibuprofen antihyperalgesic effect using inorganically functionalized diatomite
Authors: Janićijević, Jelena
Milić, Jela
Čalija, Bojan
Micov, Ana
Stepanović-Petrović, Radica
Tomić, Maja
Daković, Aleksandra
Dobričić, Vladimir
Nedić Vasiljević, Bojana 
Krajišnik, Danina
Issue Date: 28-Sep-2018
Journal: Journal of materials chemistry. B
Abstract: 
Refined diatomite from the Kolubara coal basin (Serbia) was inorganically functionalized through a simple, one-pot, non-time-consuming procedure. Model drug ibuprofen was adsorbed on the functionalized diatomite under optimized conditions providing high drug loading (∼201 mg g-1). Physicochemical characterization was performed on the starting and modified diatomite before and after ibuprofen adsorption. Dissolution testing was conducted on comprimates containing the drug adsorbed on the modified diatomite (composite) and those containing a physical mixture of the drug with the modified diatomite. The antihyperalgesic and the antiedematous activity of ibuprofen from both composites and physical mixtures were evaluated in vivo employing an inflammatory pain model in rats. Functionalization and subsequent drug adsorption had no significant effect on the diatomite ordered porous structure. Two forms of ibuprofen most likely coexisted in the adsorbed state - the acidic form and a salt/complex with aluminium. Both comprimate types showed extended ibuprofen release in vitro, but no significant influence on the duration of the ibuprofen effect was observed upon in vivo application of the composite or physical mixture. However, both the composite and the physical mixture were more effective than equivalent doses of ibuprofen in pain suppression in rats. This potentiation of the ibuprofen antihyperalgesic effect may result from the formation of the drug complex with the carrier and can be of clinical relevance.
URI: https://dspace.ffh.bg.ac.rs/handle/123456789/748
ISSN: 2050-7518
DOI: 10.1039/c8tb01376d
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University of Belgrade
Faculty of Physical Chemistry
Studentski trg 12-16
11158 Belgrade 118
PAC 105305
SERBIA
University of Belgrade Faculty of Physical Chemistry