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https://dspace.ffh.bg.ac.rs/handle/123456789/2390| Title: | Study of the Acidic, Basic, and Thermal Degradation Kinetics of Three Antihypertensive Drugs-Individually and in Combination | Authors: | Mandić-Kovacević, Nebojša Kasagić-Vujanović, Irena Gatarić, Biljana Škrbić, Ranko Popović Bijelić, Ana |
Keywords: | amlodipine besylate;fixed drug combinations;indapamide;kinetics;perindopril tert-butylamine;stability | Issue Date: | 2-Nov-2024 | Journal: | Pharmaceutics | Abstract: | The importance of fixed-dose combinations (FDCs) for the treatment of hypertension is well established. However, from a stability perspective, FDCs present a challenge since the degradation of one active pharmaceutical ingredient (API) can be affected by the presence of another API. The aim of this study was to compare the degradation behaviors and evaluate the degradation kinetics of three antihypertensive drugs, perindopril tert-butylamine (PER), amlodipine besylate (AML), and indapamide (IND). |
URI: | https://dspace.ffh.bg.ac.rs/handle/123456789/2390 | ISSN: | 1999-4923 | DOI: | 10.3390/pharmaceutics16111410 |
| Appears in Collections: | Journal Article |
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