KINETIC ASPECTS OF SILVER IONS RELEASE FROM Ag-POLY(N- ISOPROPYLACRYLAMIDE/ITACONIC ACID) HYDROGEL NANOCOMPOSITES

Abstract

In recent years, drug delivery systems have been one of the most investigated solutions for safer and more efficient therapy. Among many investigated materials, hydrogels with incorporated drugs and/or active substances can be produced in different ways to meet the criteria of biocompatibility, non-toxicity, continuous drug delivery, etc. In our previous work, the AgP(NiPAAm/IA) hydrogel nanocomposites were produced by radiolytic method, which enabled the synthesis and sterilization of materials in one technological step. Because of silver ions release, these hydrogel nanocomposites showed good antibacterial potential against both grampositive and gram-negative bacteria. In this study, we go a step forward and investigate the silver release mechanism by fitting experimentally obtained data with several commonly used kinetics models of drug release.