Spectrophotometric investigation of famotidine-Pd(II) complex and its analytical application in drug analysis

Abstract

By using different spectrophotometric methods, it was found that famotidine and palladium(II) ions form a complex, Pd(II): famotidine = 1:1. which has an absorption maximum at 345 nm. The formation of the complex between famotidine and palladium(II) chloride in Britton-Robinson buffer solution in the pH range 2.23-8.50 was studied. The conditional stability constant of the complex at the optimum pH 2.62 and ionic strength 0.5 M was found to be log K′ = 3.742 ± 0.025. The Beer's law was verified over the famotidine concentration range from 5 × 10-5 - 6 × 10-4 M. The proposed method was found to be suitable for accurate and sensitive analysis of famotidine both as the substance (RSD = 1.02-1.80%) and its dosage forms (RSD = 1.75-1.83%).