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https://dspace.ffh.bg.ac.rs/handle/123456789/1822| Title: | Study of some polyoxometallates of Keggin's type as potential antitumour agents | Authors: | Holclajtner Antunović, Ivanka Kuntić, Vesna Juranić, Zorica Filipović, Ivana Mioč, Ubavka Stanojković, Tatjana Žižak, Željko |
Keywords: | Antitumour effect;HeLa cells;Polyoxometallates | Issue Date: | 1-Jan-2004 | Journal: | Jugoslovenska Medicinska Biohemija | Abstract: | The antitumour action of three polyoxometallate compounds of Keggin's type: 12-molibdophosphoric acid (MoPA), 12-tungstophosphoric acid (WPA) and Mg salt of WPA (MgHWPA) was studied in vitro. For human cervix carcinoma (HeLa) cells survival, as well as for nonstimulated and stimulated peripheral blood mononuclear cells (PBMC), MTT test was applied and IC50 values of POMs were determinated. Index selectivity for WPA and MgHWPA are 1.9 and 1.8, calculated for nonstimulated, as well as 2.5 and 2.0, calculated for stimulated PBMS. Combination of studied POMs do not contribute to their lower IC 50 values. Apoptosis detection implies mild cytotoxic effect of WPA and more cytostatical effect of MgHWPA. Combination of each of the studied POMs with caffeine decreases HeLa survival in dose dependent way. None of the studied POMs in the used concentrations (up to 100 μmol/L) damages blood cells and/or decreases their number. |
URI: | https://dspace.ffh.bg.ac.rs/handle/123456789/1822 | ISSN: | 0354-3447 | DOI: | 10.2298/JMH0401025H |
| Appears in Collections: | Journal Article |
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