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https://dspace.ffh.bg.ac.rs/handle/123456789/1810| Title: | Synthesis, characterization, and biological activity of amino acid derivatives of the heteropolytungstophosphoric acid | Authors: | Kuntić, Vesna Stanojević, Maja Holclajtner Antunović, Ivanka Uskoković-Marković, Snežana Mioč, Ubavka Todorović, Marija Jovanović, Tanja Vukojević, Vladana |
Keywords: | Amino acids;Antiviral activity;Cellular toxicity;Heteropoly compounds;IR spectroscopy | Issue Date: | 1-Jan-2006 | Journal: | Monatshefte fur Chemie | Abstract: | Compounds of phosphotungstic acid (WPA) containing the amino acids alanine (WPA-Ala) or glycine (WPA-Gly) as counter cations were synthesized and characterized by elemental analysis, thermal analysis, and IR spectroscopy. Cellular toxicity was assessed by the trypan blue exclusion method, and the antiviral activity of WPA and the modified WPA compounds was tested against herpes simplex viruses (HSV) type 1 and type 2. Biological assays indicate that the newly synthesized compounds exhibit no evident cytotoxic effects on Vero cells and negligible antiviral activity against HSV-1 and HSV-2. © Springer-Verlag 2006. |
URI: | https://dspace.ffh.bg.ac.rs/handle/123456789/1810 | ISSN: | 0026-9247 | DOI: | 10.1007/s00706-006-0467-3 |
| Appears in Collections: | Journal Article |
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