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Please use this identifier to cite or link to this item: https://dspace.ffh.bg.ac.rs/handle/123456789/177
Title: Modelling cholesterol effects on the dynamics of the hypothalamic-pituitary-adrenal (HPA) axis
Authors: Marković, Vladimir M
Čupić, Željko
Maćešić, Stevan 
Stanojević, Ana
Vukojević, Vladana
Kolar-Anić, Ljiljana 
Keywords: Cholesterol;Hypothalamic–pituitary–adrenal (HPA) axis;circadian and ultradian rhythms;cortisol;dynamical diseases;stoichiometric network analysis
Issue Date: Mar-2016
Journal: Mathematical medicine and biology : a journal of the IMA
Abstract: 
A mathematical model of the hypothalamic-pituitary-adrenal (HPA) axis with cholesterol as a dynamical variable was derived to investigate the effects of cholesterol, the primary precursor of all steroid hormones, on the ultradian and circadian HPA axis activity. To develop the model, the parameter space was systematically examined by stoichiometric network analysis to identify conditions for ultradian oscillations, determine conditions under which dynamic transitions, i.e. bifurcations occur and identify bifurcation types. The bifurcations were further characterized using numerical simulations. Model predictions agree well with empirical findings reported in the literature, indicating that cholesterol levels may critically affect the global dynamics of the HPA axis. The proposed model provides a base for better understanding of experimental observations, it may be used as a tool for designing experiments and offers useful insights into the characteristics of basic dynamic regulatory mechanisms that, when impaired, may lead to the development of some modern-lifestyle-associated diseases.
URI: https://dspace.ffh.bg.ac.rs/handle/123456789/177
ISSN: 1477-8599
DOI: 10.1093/imammb/dqu020
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University of Belgrade
Faculty of Physical Chemistry
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11158 Belgrade 118
PAC 105305
SERBIA
University of Belgrade Faculty of Physical Chemistry