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https://dspace.ffh.bg.ac.rs/handle/123456789/17| Title: | In vivo/Ex Vivo EPR Investigation of the Brain Redox Status and Blood--Brain Barrier Integrity in the 5xFAD Mouse Model of Alzheimer's Disease | Authors: | Vesković, Ana Nakarada, Đura Pavićević, Aleksandra Prokić, Bogomir Perović, Milka Kanazir, Selma Popović Bijelić, Ana Mojović, Miloš |
Keywords: | 5xFAD.;Alzheimer’s disease;EPR;blood-brain barrier;mitochondria;spin probes | Issue Date: | 24-Mar-2021 | Journal: | Current Alzheimer research | Abstract: | Alzheimer's disease (AD) is the most common neurodegenerative disorder characterized by cognitive decline and total brain atrophy. Despite the substantial scientific effort, the pathological mechanisms underlying neurodegeneration in AD are currently unknown. In most studies, amyloid β peptide has been considered the key pathological change in AD. However, numerous Aβ-targeting treatments have failed in clinical trials. This implies the need to shift the re- search focus from Aβ to other pathological features of the disease. |
URI: | https://dspace.ffh.bg.ac.rs/handle/123456789/17 | ISSN: | 1567-2050 | DOI: | 10.2174/1567205018666210324121156 |
| Appears in Collections: | Journal Article |
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