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https://dspace.ffh.bg.ac.rs/handle/123456789/1452
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Djajic, Tatjana | en_US |
dc.contributor.author | Jovanovic, Jelena | en_US |
dc.contributor.author | Potkonjak, Biljana | en_US |
dc.contributor.author | Adnađević, Borivoj | en_US |
dc.date.accessioned | 2022-12-21T15:55:19Z | - |
dc.date.available | 2022-12-21T15:55:19Z | - |
dc.date.issued | 2015-01-01 | - |
dc.identifier.issn | 0032-3888 | en |
dc.identifier.uri | https://dspace.ffh.bg.ac.rs/handle/123456789/1452 | - |
dc.description.abstract | The isothermal kinetics of in vitro nicotinamide release from poly(acrylic-co-methacrylic acid) loaded xerogel into water was evaluated. The isothermal kinetics curves of nicotinamide release from poly(acrylic-co-methacrylic acid) xerogel were measured at different temperatures ranging from 296 K to 315 K. It was proven that the kinetics of nicotinamide release from poly(acrylic-comethacrylic acid) xerogel was a kinetically complex process which was neither controlled by the processes of drug diffusion nor with the relaxation of the xerogel. The kinetic of nicotinamide release from poly(acrylic-co-methacrylic acid) may be described by the kinetics model of reversible first order chemical reaction and the apparent activation energy have value of Ea,M5=14.1 kJ mol-1 and preexponential factor ln(AM min-1)=2.3. The rate constants of nicotinamide release (kR) and the rate constants of its reversible absorption reaction (kA) were calculated and found to fall within the range 0.019 min-1-0.033 min21 for kR and 0.014 min-1-0.016 min-1 for kA. The value of activation energy for the nicotinamide releas, Ea.R =21.25 kJ mol-1, is significantly higher than the value for the process of nicotinamide absorption (Ea,A=2.6 kJ mol-1). The rate of nicotinamide release was predetermined with the rate of nicotinamide molecules distribution between the hydrogel and surrounding solution. | en |
dc.relation.ispartof | Polymer Engineering and Science | en |
dc.title | The kinetics of isothermal nicotinamide release from poly(acrylic-co-methacrylic acid) loaded xerogel | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1002/pen.23870 | - |
dc.identifier.scopus | 2-s2.0-84918777201 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/84918777201 | - |
dc.relation.firstpage | 60 | en |
dc.relation.lastpage | 69 | en |
dc.relation.issue | 1 | en |
dc.relation.volume | 55 | en |
item.openairetype | Article | - |
item.fulltext | No Fulltext | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.orcid | 0000-0003-3322-8506 | - |
Appears in Collections: | Journal Article |
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